Glia: That other tiny engine of thought

Quick! Name a small and numerous component in the brain that allows us to think. If you said "neuron," you would be only partially correct. According to Carl Zimmer's blog at Discover, "The Loom," evidence is accumulating that thinking is also accomplished by astrocytes

—named for their starlike rays, which reach out in all directions—are the most abundant of all glial cells and therefore the most abundant of all the cells in the brain. They are also the most mysterious. A single astrocyte can wrap its rays around more than a million synapses. Astrocytes also fuse to each other, building channels through which molecules can shuttle from cell to cell.
To put glia into a broader perspective, consider Zimmer's introduction to his post on glia:

I’ve asked around for a good estimate of how many neurons are in the human brain. Ten billion–100 billion–something like that, is the typical answer I get. But there are actually a trillion other cells in the brain. They’re known as glia, which is Latin for glue–which gives you an idea of how little scientists have thought of them.

It has now been shown that astrocytes can sense incoming signals, respond with calcium waves, and produce outputs

In other words, they have at least some of the requirements for processing information the way neurons do. Alfonso Araque, a neuroscientist at the Cajal Institute in Spain . . . find that two different stimulus signals can produce two different patterns of calcium waves (that is, two different responses) in an astrocyte. When they gave astrocytes both signals at once, the waves they produced in the cells was not just the sum of the two patterns. Instead, the astrocytes produced an entirely new pattern in response. That’s what neurons—and computers, for that matter—do. If astrocytes really do process information, that would be a major addition to the brain’s computing power . . . neuroscientist Andrew Koob suggests that conversations among astrocytes may be responsible for “our creative and imaginative existence as human beings.”

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Stop Discriminating against Sick People!

Stop Discriminating against Sick People! Jonathon Alter was a guest on "the Ed Show" tonight on MSNBC. In a noisy debate with Ed, he said that the goal of healthcare reform should be "to end discrimination against sick people". He said that the path to reform was largely irrelevant. That whether or not there was a public option was largely irrelevant. That healthcare reform is a civil rights issue, and that reform had nothing to do with the mechanics of that reform. To be clear, Mr Alter stated that he was personally very much for a public option. But he was also very clear that regardless of the public option, this reform needed to pass. I agree with Jonathon. Discrimination against sick people must stop. Discrimination against people with 'pre-conditions' must stop. Discrimination against people, must stop. It's time to act. Call your congressman. Enact healthcare reform.

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Hitler and the Dining Room Table

I like Barney Frank. He says what he feels, usually in a way that makes his argument better. But it's almost a no-brainer to do a comeback on the idiocy with which he was faced in Dartmouth, Massachussetts this past week. I mean, what do you say to someone who thinks it's a valid statement to compare Obama to Hitler? A woman carrying a poster with Obama's image modified with a Hitlerian mustache stepped up to the microphone to ask why Frank supports a Nazi policy. There are so many things wrong with this it boggles the mind where to begin. Frank's response was probably the most effective. "On what planet do you spend most of your time?" he asked. Then: "Ma'am, trying to have a conversation with you would be like trying to argue with a dining room table." He then commented that her freedom to carry that poster and make such lamebrained statements was a tribute to the First Amendment and Freedom of Speech. I salute his restraint. To compare any president of the United States to Hitler is a stretch, even with the likes of Obama's predecessor. (I might consider it for Cheney, but even he does not match the level of malignancy achieved by Adolph, nor does our system allow for such people to act with unrestrained impunity, hard as that might be for some to accept.) But to compare Barack Obama to the man man of the 20th Century is such a profoundly ignorant mischaracterization that it is tempting to write off this whole experiment in potential civilization as a failure. Where does this shit come from? The Republican Party, what is left of it, is grasping at straws, sinking in the quicksand of its own inanity. We must take care to not be pulled into the quagmire in some misguided attempt to rescue it through well-intentioned but doomed bipartisan sentiments. The Republican Party has devolved into a nasty cadre of ideologues, a shrinking room of hydrophobic screechers who claw and scratch at anyone who tries to do this country a service by bringing it back to some semblance of decency. They have fed on their own conspiracy-fevered viscera for so long that they cannot even hear the words much less the sentences of opposing viewpoints. We should perhaps let them sink and drown. It would be a kindness. The fear-mongering is reminiscent of everything we've seen since 2000. Rachel Maddow, who is one of the most able of contemporary analysts on television, shows the process and the connections here. Shouting, screaming, inane blather---noise filling the spaces in which rational discourse might take place if only the decibel level could be reduced. Platitudes, sloganeering, slander, and lies are flooding these so-called town hall meetings and shoving aside reason and discovery and thought. These are not people who are interested in understanding anything, they are people bent on stopping something they've been told---been told---they should not allow.

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Support the Internet Freedom Preservation Act of 2009

Early this week, Representatives Ed Markey and Anna Eshoo introduced the Internet Freedom Preservation Act of 2009. It's common sense and it's fair, but just watch as the telecoms now do everything they can to destroy it. Why do we need this Act? Here are a few recent examples:

The issue of unrestricted Internet access has gained new traction on Capitol Hill in the wake of reports that Apple and AT&T are each blocking or preventing users from accessing services for the mega-popular iPhone, which is exclusive to AT&T at the moment. FCC chairman Julius Genachowski recently sent letters to Apple, AT&T, and Google asking why Google Voice, the company's popular free calling service, was rejected for use on the iPhone.

Representatives Markey and Eshoo made this statement about the need for this net neutrality bill:

The Internet is a success today because it was open to everyone with an idea,” said Rep. Markey. “That openness and freedom has been at risk since the Supreme Court decision in Brand X. This bill will protect consumers and content providers because it will restore the guarantee that one does not have to ask permission to innovate. The Internet has thrived and revolutionized business and the economy precisely because it started as an open technology,” Rep. Eshoo said. “This bill will ensure that the non-discriminatory framework that allows the Internet to thrive and competition on the Web to flourish is preserved at a time when our economy needs it the most.”

Here's a summary of the bill:

H.R. 3458, the Internet Freedom Preservation Act, is designed to assess and promote Internet freedom for consumers and content providers. The bill states that it is the policy of the United States to protect the right of consumers to access lawful content, run lawful applications, and use lawful services of their choice on the Internet while preserving and promoting the open and interconnected nature of broadband networks, enabling consumers to connect to such networks their choice of lawful devices, as long as such devices do not harm the network. The legislation also directs the Federal Communications Commission (FCC) to promulgate several rules relating to enforcement and implementation of the legislation, including rules to ensure that providers of Internet access service fulfill the duties and disclose meaningful information to consumers about a provider’s Internet access service in clear, uniform, and conspicuous manner.

To do your part, click on this tool to determine the phone number of your representative, then call to ask for his or her position on this bill. You are then given a further option to report the result to Free Press/Save the Internet. I made the call and spoke directly with a legislative assistant. She didn't know the answer (re Representative Russ Carnahan), but promised to find out and report back to me. The entire process only took a couple minutes. You can also sign a Petition that will be delivered to Congress by visiting Save the Internet. Again, it only takes a minute. Your grass roots investment of a few minutes can counteract tens of millions of dollars the telecoms will spend on lobbyists, misleading media campaigns and wads of cash that the are putting into the palms of your elected representatives. Be empowered!

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