“Safe and Effective” Drugs
At least 100 drugs once considered "safe and effective" for their intended uses (based on clinical trial data submitted by manufacturers) have been taken off the market due to how dangerous they were. Well-known examples include Thalidomide, Vioxx and Bextra, which have caused tens of thousands of deaths and injuries.
The presenter in this video is Simone Gisondi, host of the podcast "The Health Confidential with Simone Gisondi."
Based on FDA and global regulatory data, here are 20 recently withdrawn drugs (sorted most recent first, with year and reason):
1. Oxbryta (2024) - Increased deaths/complications in sickle cell patients.
2. Makena (2023) - Lack of effectiveness.
3. Ranitidine (Zantac, 2020) - Carcinogen contamination.
4. Lorcaserin (Belviq, 2020) - Cancer risk.
5. Ingenol mebutate (2020) - Skin cancer risk.
6. Flupirtine (2018) - Liver toxicity.
7. Tetrazepam (2013) - Skin reactions.
8. Drotrecogin alfa (2011) - No efficacy.
9. Gemtuzumab ozogamicin (2010) - Death risk.
10. Propoxyphene (2010) - Heart risks.
11. Rosiglitazone (2010) - Heart attacks.
12. Sibutramine (2010) - Heart attack/stroke.
13. Sitaxentan (2010) - Liver damage.
14. Lumiracoxib (2008) - Liver damage.
15. Rimonabant (2008) - Depression/suicide.
16. Aprotinin (2008) - Death risk.
17. Pergolide (2007) - Heart valve damage.
18. Tegaserod (2007) - Heart attack/stroke.
19. Clobutinol (2007) - Arrhythmias.
20. Alatrofloxacin (2006) - Liver toxicity.






