Jay Bhattacharya Distinguishes Two Types of Gain of Function Research

I did not appreciate this distinction. Until I saw Bari Weiss' interview of Jay Bhattacharya, I assumed that all gain of function research was dangerous.

I created this transcript of the above interview:

Bari Weiss: Should gain a function research be banned, okay?

Jay Bhattacharya: So you have to be careful here. There's some gain of function research which is entirely benign, has no chance of causing a pandemic and would advance a use that is vital tool for advancing human health, right? So, for instance you have some protein you want expressed so that you can use it as a treatment, like insulin, is a good example of this. You change the DNA of a of an E coli, use the E coli bacteria to produce the insulin cheaply. That's gain of function work. There's nothing wrong with that.

But there is gain of function work that has the potential to cause a pandemic. You take a virus you find in a bat cave in China, Coronavirus, you add a biochemical element. This Is not theoretical. You add an element to it that makes it more transmissible among human cells and then you do that in a setting where it might infect the lab technician who takes it home without knowing it infects their family and causes a pandemic that causes so much damage.

That kind of research, or any research that has any capacity of causing a pandemic through gain of function, work should be banned. I think it has no place among the toolkit of scientists. You have a few scientists taking risks on behalf of the entire human population, and they do it in an unregulated way that makes absolutely no sense to me. Even if you don't agree that that is what led to this past pandemic--I happen to think it does--But even if you don't agree going forward, why would you say yes, you should take that risk? There aren't enough benefits to that kind of research to warrant causing a pandemic that can kill 10 million, 20 million people, if you include the lockdown harms and caused trillions of dollars of damage and set society back for so long. What knowledge gain would be worth that?

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How to Marginalize Ideas and People to Create an Illusion of Consensus, Hurting People in the Process

A story of hubris by the powers that be. This could also be characterized the sort of thing Jonathan Haidt would characterize as "structural stupidity":

People who try to silence or intimidate their critics make themselves stupider, almost as if they are shooting darts into their own brain.

What follows is an Excerpt From The Free Press. "Government Power v. People Power," By Dr. Jay Bhattacharya:

From the beginning of the Covid-19 pandemic, I was a vocal critic of lockdowns and school closures that I believed would cause more harm than good. In October 2020, with Sunetra Gupta of Oxford University and Martin Kulldorff of Harvard University, I wrote the Great Barrington Declaration, which proposed protecting vulnerable people while lifting lockdowns for the majority of the population. In other words, it advocated a return to classic principles of pandemic management that had worked to limit the harm of other respiratory virus pandemics. Tens of thousands of scientists signed on.

Four days after we wrote it, the head of the National Institute of Health, Francis Collins, wrote to Anthony Fauci, labeling us as “fringe epidemiologists” and calling for “a quick and devastating published takedown” of the declaration. A propaganda campaign quickly ensued, with various media sources falsely accusing me of wanting to let the virus rip. It wasn’t just the press. Recently I learned in these pages that Twitter placed me on a secret blacklist to limit the reach of my tweets.

So what did I learn in 2022? I learned in a very concrete and painful way the effects of Washington and Silicon Valley working together to marginalize unpopular ideas and people to create an illusion of consensus.

This censorship and smear campaign deprived the world of a needed debate over Covid policy and might have avoided much unnecessary suffering by children, the poor, and the working class harmed by lockdowns.

[Dr. Jay Bhattacharya is a professor of health policy at Stanford University, where he has taught in the medical school for over two decades].

Here is an excerpt from the Great Barrington Declaration:

Fortunately, our understanding of the virus is growing. We know that vulnerability to death from COVID-19 is more than a thousand-fold higher in the old and infirm than the young. Indeed, for children, COVID-19 is less dangerous than many other harms, including influenza.

As immunity builds in the population, the risk of infection to all – including the vulnerable – falls. We know that all populations will eventually reach herd immunity – i.e. the point at which the rate of new infections is stable – and that this can be assisted by (but is not dependent upon) a vaccine. Our goal should therefore be to minimize mortality and social harm until we reach herd immunity.

The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk. We call this Focused Protection.

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