Rene Descartes held that the human mind was separate from bodily processes.  Dr. Antonio R. Damasio disagreed, as set forth in Descartes’ Error: Emotion, Reason and the Human Brain (1994). In this book, Damasio introduced the cases of Phineas Gage (long dead) and “Elliot” (a living patient), who both suffered brain damage to the ventromedial prefrontal area of their brains. 

Gage’s brain damage occurred when a metal tamping rod was accidentally shot through his brain during a blasting operation (he recovered and lived many years).  Elliot’s damage occurred as a result of a brain tumor. They were both left with high level intellectual functioning but little ability to experience emotion. 

[Gage] seemed to be like a child, with no stable sense of what was important and what was not. He was fitful, intemperate, obscene. It was as if he didn’t care about one thing more than another. He seemed bizarrely detached from the reality of his conduct. So he could not make good choices, and he could not sustain good relationships . .

Elliot had been a good role model, husband and father before his tumor.  After the tumor, he was

weirdly cool, detached, and ironic, indifferent even to intrusive discussion of personal matters- as if such remarks were not really about him. He had not previously been this way; he had been an affectionate husband and father. He retained lots of cognitive functions: he could perform calculations, had a fine memory for dates and names, and the ability to