http://dangerousintersection.org/2008/04/28/more-merck-lies-uncovered-regarding-vioxx/ Human Animals at the Crossroads of Culture, Science, Religion and Media Thu, 20 Nov 2008 09:26:47 +0000 http://wordpress.org/?v=2.6.3 http://dangerousintersection.org/2008/04/28/more-merck-lies-uncovered-regarding-vioxx/#comment-17951 Niklaus Pfirsig Tue, 29 Apr 2008 12:57:23 +0000 http://dangerousintersection.org/?p=2515#comment-17951 Redcently, my DP gave me some samples of Celebrex for a pulled muscle. knowing that Celebrex is closely related to Vioxx, I decided to do a little digging on the net. If I understand the research corectly, the safety studies were done using 15 mg doeses, but the prescription product is 220 mg. Knowing a little about bio chemistry, but being no expert, I read up on the pharmacological action of COX-2 inhibitors such as Celebrex and Vioxx. I wass somewhat disturbed to find that a rather obvious side effect was not followed up in the studies. There was an indication that cox2 inhibitors caused an electrolyte imbalance which could result in a sharp rise in blood pressure. Also, absolutely no research was indicate concerning the effects on the cox-3 enzyme pathways. It appears to me that the research was selectived on marketability criteria and without the safety of the comsumers at all. Redcently, my DP gave me some samples of Celebrex for a pulled muscle. knowing that Celebrex is closely related to Vioxx, I decided to do a little digging on the net. If I understand the research corectly, the safety studies were done using 15 mg doeses, but the prescription product is 220 mg. Knowing a little about bio chemistry, but being no expert, I read up on the pharmacological action of COX-2 inhibitors such as Celebrex and Vioxx. I wass somewhat disturbed to find that a rather obvious side effect was not followed up in the studies. There was an indication that cox2 inhibitors caused an electrolyte imbalance which could result in a sharp rise in blood pressure. Also, absolutely no research was indicate concerning the effects on the cox-3 enzyme pathways.
It appears to me that the research was selectived on marketability criteria and without the safety of the comsumers at all.

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